Assessment of CuFeSe₂ ternary nanozymes for multimodal triple negative breast cancer theranostics.

ABSTRACT: Triple negative breast cancer (TNBC) remains a challenge for clinical diagnosis and therapy due to its poor prognosis and high mortality rate. Hence, new methods to achieve TNBC imaging and imaging-guided TNBC therapy are urgently needed. Currently, the combination of chemotherapy with phototherapy/catalytic therapy has become a promising strategy for cancer treatment. Here, multifunctional CuFeSe₂ ternary nanozymes (CuFeSe₂-AMD3100-Gem nanosheets) were prepared as high-performance nanotheranostic agents for imaging-guided synergistic therapy of TNBC in vitro and in vivo. CuFeSe₂-AMD3100-Gem nanosheets not only exhibited outstanding CXCR4-targeted capability and superior photothermal properties, but also produced exact chemical cytotoxicity through the load

SUBMITTER: Yang C 

PROVIDER: S-EPMC11965050 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature