Identification of CCDC58 as a potential predictive biomarker of immune cell infiltration in hepatocellular carcinoma.

ABSTRACT:

Background

Mitochondrial dynamics play a critical role in the proper functioning of both the innate and adaptive immune systems. Coiled-coil domain-containing 58 (CCDC58), a mitochondrial-related gene, has been implicated in various diseases, including cancer and infections. However, its predictive value in immune cell infiltration in hepatocellular carcinoma (HCC) remains unexplored.

Methods

In this study, RNA-seq data from The Cancer Genome Atlas and multiple online datasets were analyzed to explore the correlation between CCDC58 and clinicopathological features, prognosis, related signaling pathways and immune cell infiltration in HCC. Furthermore, primary T cells were isolated and cell experiments such as cytotoxic assays and transwell assays were conducted to verify piv

SUBMITTER: Liu Z 

PROVIDER: S-EPMC11965056 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature