Observational study on the efficacy and safety of FOLFOXIRI therapy for locally advanced rectal cancer: The Kanagawa Yokohama Colorectal Cancer Study Group (KYCC)1802.

ABSTRACT:

Purpose

Although chemoradiotherapy is considered an efficacious treatment option for patients with locally advanced rectal cancer, the associated radiological toxicities and late anal dysfunction are concerning issues. Herein, we examined the efficacy and safety of folinic acid, 5-fluorouracil, oxaliplatin, and irinotecan (FOLFOXIRI) as upfront therapy for marginally unresectable local rectal cancers without distant metastasis.

Methods

This multicenter, prospective, observational study was designed by the Yokohama Colorectal Cancer Study Group. The primary endpoint was the conversion rate. Secondary endpoints were the R0 resection rate, response rate, pathological response rate, postoperative complication rate, relapse-free survival, local progression-free rate, and circumfe

SUBMITTER: Okamoto H 

PROVIDER: S-EPMC11965198 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature