Metformin alleviates inflammatory response and severity rate of COVID-19 infection in elderly individuals.

ABSTRACT: To evaluate the relationship between metformin and the outcome of coronavirus disease 2019 (COVID-19) infection. The study included 413 patients with type 2 diabetes among the 5217 patients enrolled in a COVID-19 study, and analyzed whether receiving metformin therapy prior to infection was associated with risk of ICU admission, development of pneumonia and length of hospital stay. The study also examined the correlation between metformin treatment and levels of IL-6, CRP, serum ferritin (SF), lymphocyte, CD4 at admission, as well as the increase in open reading frame 1ab gene cycle threshold (ORF1abCT) after one week of hospitalization. There were no differences in age, sex, BMI, comorbidities, number of vaccine doses or eGFR between patients receiving and not receiving metformin therapy.

SUBMITTER: Chen X 

PROVIDER: S-EPMC11965306 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature