IgE autoantibodies to nuclear antigens in patients with different connective tissue diseases: re-evaluation and novel findings.

ABSTRACT:

Introduction

Connective tissue diseases (CTD) are characterised by the overproduction of multiple autoantibodies, especially antinuclear antibodies (ANA) of the IgG type. Meanwhile, also IgE autoantibodies have been described. The aim was therefore, to establish an ELISA for the demonstration of IgE autoantibodies to SSA/Ro, SSB/La, RNP proteins and dsDNA in sera from patients with systemic lupus erythematosus (SLE), Sjoegren's syndrome (SS), and mixed connective tissue disease (MCTD) to investigate their frequency and clinical relevance.

Methods

Serum samples from 110 patients with SLE, 118 patients with SS, 41 patients with MCTD, and 73 controls were analysed by ELISA for IgE autoantibodies against dsDNA, SSA/Ro52, and SSA/Ro60, SSB/La, and RNP proteins using recombinant a

SUBMITTER: Kramer K 

PROVIDER: S-EPMC11965355 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature