The association between low-concentration heavy metal exposure and chronic kidney disease risk through α-klotho.

ABSTRACT: Although the association between pollution exposure and chronic kidney disease (CKD) has been explored, previous studies have focused on specific effects observed via in vitro or animal experiments. We first conducted a priority screening of pollutants for population CKD risk by using machine learning approaches. We then used the National Health and Nutrition Examination Survey (NHANES) 2007-2016 data from 2415 adults aged 40 years and over to study the joint effects of low-concentration metal exposure and the mediating effects of α-klotho by using Bayesian kernel machine regression (BKMR) and mediation analyses. Priority screening revealed that cadmium (Cd), mercury (Hg), lead (Pb), and thallium (Tl) were associated with the highest risk of developing CKD. The BKMR model revealed a negati

SUBMITTER: Liu S 

PROVIDER: S-EPMC11965371 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature