Leptin Levels in Acute and Recovered Eating Disorders: An Arm-Based Network Meta-Analysis.

ABSTRACT:

Objective

This study aimed to provide a BMI-adjusted meta-analytical calculation of blood leptin levels across different eating disorders (EDs) including anorexia nervosa (AN), bulimia nervosa (BN), binge eating disorder (BED), recovered EDs, and healthy controls (HCs). The goal was to understand BMI-independent leptin alterations and their potential as biomarkers.

Method

PubMed and ClinicalTrials.gov were searched for studies reporting serum leptin in AN, BN, BED, or recovered EDs. A multilevel network meta-analysis using a linear mixed-effects meta-regression model, adjusting for BMI, sex, and assay type, was performed on 146 studies (5048 patients, 3525 controls).

Results

Significant differences in leptin levels were found across EDs. AN patients exhibited the lowe

SUBMITTER: Cassioli E 

PROVIDER: S-EPMC11965547 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature