Retinal thermal deformations measured with phase-sensitive optical coherence tomography in vivo.

ABSTRACT: Controlling the tissue temperature rise during retinal laser therapy is essential for predictable outcomes, especially at non-damaging settings. We demonstrate a method for determining the temperature rise in the retina using phase-sensitive optical coherence tomography (pOCT) in vivo. Measurements based on the thermally induced optical path length changes (ΔOPL) in the retina during a 10-ms laser pulse allow detection of the temperature rise with a precision less than 1 °C, which is sufficient for calibration of the laser power for patient-specific non-damaging therapy. We observed a significant difference in confinement of the retinal deformations between the normal and the degenerate retina: in wild-type rats, thermal deformations are localized between the retinal pigment epithelium (RP

SUBMITTER: Zhuo Y 

PROVIDER: S-EPMC11965573 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature