Global, regional and country burden of high BMI-related liver cancer among individuals aged above 70: trends from 1990 to 2021 and projections to 2044.

ABSTRACT:

Background

Liver cancer (LC) is a major global health concern, being the fourth leading cause of cancer-related mortality. Older adults are more susceptible, though mortality rates for those over 70 are declining. However, disability from non-communicable diseases remains high. High body mass index (BMI) is a notable risk factor for LC, with high BMI-related liver cancer (HB-LC) being a major concern.

Methods

This study utilized Global Burden of Disease (GBD) 2021 dataset to assess the impact of HB-LC on individuals aged 70 and older from 1990 to 2021, with forecasts extending to 2044. Disease burden across socio-demographic index (SDI) regions was evaluated using age-standardized disability-adjusted life years (DALYs). Joinpoint regression and age-period-cohort models were

SUBMITTER: He KJ 

PROVIDER: S-EPMC11965621 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature