Perineural Invasion for Risk Stratification in Cutaneous Squamous Cell Carcinoma: A Scoping Review.

ABSTRACT:

Background

Microscopic perineural invasion (mPNI) is a histopathological characteristic that can be found in cutaneous squamous cell carcinoma (cSCC). In the eighth edition of the American Joint Committee on Cancer (AJCC), mPNI defined as the involvement of nerves ≥0.1 mm and nerves deeper than the dermis is included in risk stratification of cSCC. The question remains whether other mPNI features are important for optimal cSCC staging. We aimed to summarize the evidence from published studies on the independent association between various mPNI features and the risk of recurrence, metastasis and disease-specific death in patients with cSCC.

Summary

Embase, PubMed, and Web of Science were searched from January 2023 to February 2024 to identify studies that reported the prognos

SUBMITTER: Cruts EC 

PROVIDER: S-EPMC11965817 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature