Serum metabolomics after exercise in ambulatory individuals with cerebral palsy.

ABSTRACT:

Aim

To evaluate whether serum metabolomics differ between ambulatory individuals with cerebral palsy (CP) compared with individuals with typical development and whether functional capacity is associated with metabolite abundance.

Method

Thirty-eight adolescents and young adults were enrolled (CP: n = 19; typical development: n = 19). After functional capacity testing (10-meter walk, sit-to-stand, and peak knee flexion/extension torques), blood was drawn. Targeted serum metabolomics on hydrophilic metabolites were performed by high-performance liquid chromatography coupled with high-resolution and tandem mass spectrometry. Metabolite dimensionality reduction, pathway analysis, fold change, and t-tests evaluated changes in metabolite abundance. Associations were tested between

SUBMITTER: Hanaoka C 

PROVIDER: S-EPMC11965978 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature