Causal association of obesity and chronic pain mediated by educational attainment and smoking: a mediation Mendelian randomization study.

ABSTRACT:

Background

Obesity and chronic pain are related in both directions, according to earlier observational research. This research aimed to analyze the causal association between obesity and chronic pain at the genetic level, as well as to assess whether common factors mediate this relationship.

Methods

This study used bidirectional two sample Mendelian randomization (MR) technique to analyze the association between obesity and chronic pain. Obesity's summary genome-wide association data were obtained from European ancestry groups, as measured by body mass index (BMI), waist-to-hip ratio, waist circumference (WC), and hip circumference (HC), genome-wide association study data for chronic pain also came from the UK population, including chronic pain at three different sites (back

SUBMITTER: Lyu Y 

PROVIDER: S-EPMC11965988 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature