Respiratory Syncytial Virus Incidence in Young Children in the United States: Impact of Methodologies and Patient Characteristics.

ABSTRACT:

Objectives

This study aimed to estimate the incidence of respiratory syncytial virus (RSV) infections in US inpatient and outpatient settings.

Methods

We established national cohorts of privately insured children < 5 years (2011-2019) to estimate annual and seasonal incidences of lower respiratory tract infection (LRTI), RSV-LRTI, and RSV acute respiratory infection (RSV-ARI), stratified by age and high-risk conditions per American Academy of Pediatrics definitions. Sensitivity analyses varied episode definitions and assessed the impact of immunoprophylaxis and RSV under-ascertainment.

Results

Among 6,767,107 children, annual RSV-LRTI rates dropped with increasing age in both inpatient (7.9 for age < 1 year to 0.2 for age 4 per 1000 person-years) and outpatient settin

SUBMITTER: Nduaguba SO 

PROVIDER: S-EPMC11966010 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature