Regulatory effects on virulence and phage susceptibility revealed by <i>sdiA</i> mutation in <i>Klebsiella pneumoniae</i>.

ABSTRACT:

Introduction

The World Health Organization has identified multi-drug resistant Klebsiella pneumoniae strains as the highest priority in 2024. Understanding the regulatory routes of virulence features is crucial for the development of novel anti-virulence strategies. SdiA, a LuxR-like quorum sensing (QS) receptor that responds to N-acyl-homoserine lactones (AHLs), is involved in the regulation of virulence traits in some Gram-negative bacteria. The function of this receptor in the virulence of K. pneumoniae remains uncertain. The objective of the present study was to elucidate the function of SdiA in K. pneumoniae biofilm formation and virulence.

Methods

To this end, a genetic knockout of sdiA was conducted, and virulence-related phenotypic

SUBMITTER: Silva-Bea S 

PROVIDER: S-EPMC11966055 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature