Remodeling of immune system functions by extracellular vesicles.

ABSTRACT:

Introduction

The treatment of chronic viral infections can often bring viral replication under control. However, chronic immune activation persists and can lead to the development of comorbid conditions, such as cardiovascular disease and cancer. This is particularly true for people living with HIV (PLWH), who have significantly more extracellular vesicles from membrane budding, also called plasma microparticles (MPs), than healthy individuals (HDs), and a much more immunomodulatory phenotype. We hypothesized that the number and phenotypic heterogeneity of MPs can trigger a functional remodeling of immune responses in PLWH, preventing full immune restoration.

Methods

We investigated the rapid impact of three types of MPs - derived from membrane budding in platelets (CD41a

SUBMITTER: Neyrinck-Leglantier D 

PROVIDER: S-EPMC11966064 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature