Development of a mitochondria-related gene signature for prognostic assessment in diffuse large B cell lymphoma.

ABSTRACT:

Background

Mitochondria-related genes (MitoRGs) play a critical role in the pathogenesis of various cancer types. This study aims to develop a novel prognostic model based on a MitoRGs signature for patients with diffuse large B cell lymphoma (DLBCL).

Methods

Clinical data and gene expression profiles of DLBCL patients were obtained from four datasets in the Gene Expression Omnibus (GEO) database. The Least Absolute Shrinkage and Selection Operator (Lasso) Cox regression analysis, along with multivariate Cox regression analysis, was employed to develop a prognostic MitoRGs signature for patients with DLBCL within the training cohort. The prognostic efficacy of the model was assessed using Kaplan-Meier survival analysis and Receiver Operating Characteristic (ROC) curve analys

SUBMITTER: Wang F 

PROVIDER: S-EPMC11966244 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature