Analysis of global trends in acute lymphoblastic leukemia in children aged 0-5 years from 1990 to 2021.

ABSTRACT:

Background

Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with a significant global burden. This study evaluates global, regional, and national trends in the prevalence, mortality, and disability-adjusted life years (DALYs) of childhood ALL from 1990 to 2021, providing insights into disparities and progress across different socio-demographic and geographic contexts.

Methods

Data were sourced from the Global Burden of Disease study. Trends in prevalence, mortality, and DALYs were analyzed by socio-demographic index (SDI) regions, geographic areas, and countries. Estimated annual percentage changes (EAPCs) were used to quantify temporal trends.

Findings

Between 1990 and 2021, the global number of childhood ALL cases increased by 59.06%, reaching

SUBMITTER: Ding F 

PROVIDER: S-EPMC11966407 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature