Long-term prognosis of lupus nephritis: comparison between pediatric, adult, and advanced age onset.

ABSTRACT:

Background and hypothesis

Lupus nephritis (LN) presents with varied outcomes depending on the age at diagnosis. We aimed to evaluate long-term kidney survival across three age groups.

Methods

Patients were categorized based on their age at lupus nephritis diagnosis: ≤18 years (childhood), >18 to <45 (adulthood), and ≥45 years (elderly). The three groups' CKD (eGFR <60 ml/min/1.73 m² for at least 3 months) or death-free survival was estimated using Kaplan-Meier curves and compared with the log-rank test. To evaluate the independent prognostic role of age, adjusted for other predictors of chronic kidney disease (CKD) or death, we used multivariate Cox regression analysis.

Results

This retrospective cohort study analyzed 260 patients followed for a median of 1

SUBMITTER: Calatroni M 

PROVIDER: S-EPMC11966454 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature