The evolving landscape of genetic biomarkers for immunotherapy in primary and metastatic breast cancer.

ABSTRACT:

Background

Major advances have been achieved in the characterization of primary breast cancer genomic profiles. Limited information is available on the genomic profile of tumors originating from different metastatic locations in recurrent/metastatic (R/M) breast cancer, especially in Asian patients. This study aims to decipher the mutational profiles of primary and R/M breast cancer in Chinese patients using next-generation sequencing.

Methods

A total of 563 breast cancer patients were enrolled, and 590 tumor tissues and matched peripheral blood samples were collected and subjected to targeted sequencing with a panel of 1,021 cancer-related genes. The mutation spectrum, DNA damage response (DDR) genes, commonly altered signal pathways, and immunotherapy-related markers were

SUBMITTER: Jin L 

PROVIDER: S-EPMC11966456 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature