Functional vs Structural Cortical Deficit Pattern Biomarkers for Major Depressive Disorder.

ABSTRACT:

Importance

Major depressive disorder (MDD) is a severe mental illness characterized more by functional rather than structural brain abnormalities. The pattern of regional homogeneity (ReHo) deficits in MDD may relate to underlying regional hypoperfusion. Capturing this functional deficit pattern provides a brain pattern-based biomarker for MDD that is linked to the underlying pathophysiology.

Objective

To examine whether cortical ReHo patterns provide a replicable biomarker for MDD that is more sensitive than reduced cortical thickness and evaluate whether the ReHo MDD deficit pattern reflects regional cerebral blood flow (RCBF) deficit patterns in MDD and whether a regional vulnerability index (RVI) thus constructed may provide a concise brain pattern-based biomarker for MD

SUBMITTER: Kochunov P 

PROVIDER: S-EPMC11966481 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature