Apoptosis markers in children with metabolic-associated fatty liver disease: a preliminary study.

ABSTRACT:

Introduction

Metabolic-associated fatty liver disease (MAFLD) is a new disease definition. The development of hepatic steatosis is complex and may also be influenced by apoptotic mechanisms.

Aim

We aimed to assess serum concentrations of selected apoptosis markers, cytokeratin-18 fragments (M30) and agiopoietin-2 (Ang2) in children and adolescents with obesity and to evaluate the association of these parameters with paediatric MAFLD.

Material and methods

The prospective study included 76 overweight/obese children with suspected liver disease. MAFLD was diagnosed according to the latest consensus. The concentrations of M30 and Ang2 in serum were measured using an enzyme-linked immunosorbent assay (ELISA).

Results

Liver steatosis was diagnosed in abdominal ultras

SUBMITTER: Zdanowicz K 

PROVIDER: S-EPMC11966513 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature