Derivatives of Pyrazole-Based Compounds as Prospective Cancer Agents.

ABSTRACT: Five pyrazole-based compounds, 3,5-dimethyl-1H-pyrazole, L1; 3,5-diphenyl-1H-pyrazole, L2; 3-(trifluoromethyl)-5-phenyl-1H-pyrazole, L3; 3-(trifluoromethyl)-5-methyl-1H-pyrazole, L4; and 3,5-ditert-butyl-1H-pyrazole, L5 were synthesized from a typical condensation reaction of β-diketone derivatives with hydrazine hydrate reagent and characterized using various spectroscopic techniques such as FT-IR, UV-vis, ¹H and ¹³C NMR, and LC-MS spectroscopy. L1 was further analyzed by single-crystal X-ray diffraction, and the N1-N1' bond distance was found to be 1.361(3) Å and correlated well with other pyrazole-based compounds. The short-term cytotoxicity of 10 μM pyrazole compounds (L1-L5

SUBMITTER: Ramoba LV 

PROVIDER: S-EPMC11966572 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature