Long-Term Engagement of Diverse Study Cohorts in Decentralized Research: Longitudinal Analysis of "All of Us" Research Program Data.

ABSTRACT:

Background

The generalizability of clinical research hinges on robust study designs, which include the recruitment and maintenance of a representative study population. This study examines the evolution of the demographic characteristics of 329,038 participants who enrolled and participated in The All of Us Research Program (AoURP), a decentralized study aimed at representing the diversity of the United States.

Objective

The primary objectives of this study were to assess alterations in the demographic composition of the cohort at different protocol stages within AoURP, while analyzing completion rates and timeframes for survey and substudy completion. Additionally, we examined how participant interactions with the program impacted engagement and survey responses.

Methods

SUBMITTER: Yadav V 

PROVIDER: S-EPMC11966662 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature