Potassium-Doped MnO₂ Nanoparticles Reprogram Neutrophil Calcium Signaling to Accelerate Healing of Methicillin-Resistant <i>Staphylococcus aureus</i>-Infected Diabetic Wounds.

ABSTRACT: Neutrophils, as first-line immune cells, typically lose their edge within the diabetic wounds accompanied by methicillin-resistant Staphylococcus aureus (MRSA) infections (the D/M setting), playing the role of "more foe than friend" during the healing process. Specifically, reduced influx of calcium ions (Ca²⁺) and impaired calcium homeostasis yield the dysfunction of neutrophil sequential behaviors in pathogen killing and wound healing, manifesting as suppressed chemotaxis, decreased intracellular reactive oxygen species (ROS) generation, prolonged apoptosis, and retention of neutrophil extracellular traps (NETs). To address this challenge, this study fabricated potassium (K)-doped manganese dioxide nanoparticles (MnO₂ NPs), which activated transmembrane Ca

SUBMITTER: Wei J 

PROVIDER: S-EPMC11966767 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature