Microwave ablation of non-small cell lung cancer enhances local T-cell abundance and alters monocyte interactions.

ABSTRACT:

Background

Minimally invasive thermal therapies show great prospect in non-small cell lung cancer (NSCLC) treatment. However, changes in immune cell populations following microwave ablation (MWA) in NSCLC microenvironment are not fully revealed.

Objective

The present study was conducted to identify changes in immune cell populations and analyse dysregulated genes in immune cells after MWA in NSCLC microenvironment.

Methods

The patients received fractionated MWA in two treatments separated by 3 weeks. Tumor biopsy samples were obtained through core-needle biopsy before each fractionated MWA procedure at the same site and used for single-cell RNA sequencing with the 10x Genomics pipeline.

Results

A total of 9 major cell types were identified after MWA, which incl

SUBMITTER: Guo RQ 

PROVIDER: S-EPMC11966799 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature