Plasma cytokine levels and PCOS risk: Mendelian randomization analysis reveals IL6R as a preventive factor.

ABSTRACT:

Background

Polycystic ovary syndrome is a prevalent gynecological condition affecting primarily women of childbearing age. It is characterized by elevated androgen levels, ovulatory dysfunction, and morphological abnormalities. Despite extensive research from various perspectives, the etiology and pathogenesis of PCOS remain unclear. While controversial, many believe that individuals with PCOS exhibit a chronic low-grade inflammatory state. Cytokines play diverse roles in the initiation and progression of inflammation, contributing to this inflammatory milieu. Therefore, the aim of this study was to utilize publicly available genome-wide association study data to explore the potential causal relationship between cytokines and PCOS.

Methods

To accurately investigate the causa

SUBMITTER: Li X 

PROVIDER: S-EPMC11966818 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature