Enlarged choroid plexus is linked with poorer physical function in rural older adults: a population-based study.

ABSTRACT:

Background

The choroid plexus (ChP) plays an important role in producing cerebrospinal fluid (CSF) and physical dysfunction has been associated with alterations in CSF circulation. However, no population-based studies have thus far examined the association of ChP with physical function in older people.

Methods

This population-based cross-sectional study included 1217 participants (age ≥ 60 years; 57.35% women) in the MRI substudy of the Multimodal Interventions to delay Dementia and disability in rural China. ChP volume was automatically segmented using three-dimensional T1-weighted sequences. Physical function was assessed using the Short Physical Performance Battery (SPPB). Data were analyzed using general linear regression and mediation models.

Results

Controlling

SUBMITTER: Xie Q 

PROVIDER: S-EPMC11966853 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature