The relationship between kidney function and the soluble (pro)renin receptor in young adults: the African-PREDICT study.

ABSTRACT: High renin angiotensin-aldosterone system (RAAS) activity is associated with target organ damage. Soluble (pro)renin receptor [s(P)RR] forms part of the RAAS cascade and is associated with kidney damage through both angiotensin II-dependent and -independent pathways. Additionally, s(P)RR levels are higher in hypertension and chronic kidney disease (CKD) patients. However, little is known regarding ethnic and sex differences in s(P)RR levels and its potential associations with kidney function in young healthy adults. Identifying these associations in young populations is essential for identification of areas of intervention to prevent CKD. This study aimed to compare levels of s(P)RR across ethnic and sex groups and determine s(P)RR associations with markers of kidney function, including es

SUBMITTER: Mokgonyana PJ 

PROVIDER: S-EPMC11966904 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature