Impact of tumor localization on antitumor immunity with conditionally activated CTLA-4 blockade.

ABSTRACT:

Background

Immune checkpoint blockade (ICB) can induce antitumor efficacy but also induces immune-related adverse events. Systemically administered ICB can activate immune cells throughout the host. Conditionally active ICB with proteolytically cleaved masking domains can potentially reduce the adverse events seen with anti-cytotoxic T-lymphocyte associated protein 4 (CTLA-4) antibody.

Methods

We examined how different formats of a conditionally activated dual variable domain IgG (DVD) that binds CTLA-4 and the tumor-associated antigen prostate stem cell antigen (PSCA) can lead to efficacy in syngeneic subcutaneous and metastatic murine tumor models. We also defined the capacity of these DVDs to modulate immune responses by multiparameter flow cytometry.

Results

Condi

SUBMITTER: Arias-Badia M 

PROVIDER: S-EPMC11966968 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature