Lipidomic analysis reveals metabolism alteration associated with subclinical carotid atherosclerosis in type 2 diabetes.

ABSTRACT:

Background

Disruption of lipid metabolism contributes to increased cardiovascular risk in diabetes.

Methods

We evaluated the associations between serum lipidomic profile and subclinical carotid atherosclerosis (SCA) in type 1 (T1D) and type 2 (T2D) diabetes, and in subjects without diabetes (controls) in a cross-sectional study. All subjects underwent a lipidomic analysis using ultra-high performance liquid chromatography-electrospray ionization tandem mass spectrometry, carotid ultrasound (mode B) to assess SCA, and clinical assessment. Multiple linear regression models were used to assess the association between features and the presence and burden of SCA in subjects with T1D, T2D, and controls separately. Additionally, multiple linear regression models with interaction te

SUBMITTER: Barranco-Altirriba M 

PROVIDER: S-EPMC11967040 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature