Yeast hydrolysate and exercise ameliorate high-fat diet-induced obesity in C57BL/6 mice.

ABSTRACT:

Background

Yeast hydrolysate (YH) has been shown to be effective in inhibiting fat accumulation. This study aimed to investigate the effects of YH and exercise on high-fat diet-induced obesity and their underlying mechanisms in C57BL/6J mice.

Methods

In this study, 6-week-old C57BL/6 mice were divided into 7 groups; a normal group fed a normal chow diet, an HFD group (CON) fed ad libitum, an exercise group (15m/min, 30min), an HFD supplemented with low dose of YH (100 mg/kg, YHL), an HFD supplemented with high dose of YH (200 mg/kg, YHH), and a combination of exercise and YHH group. After 12 weeks of HFD and YH administration, white adipocytes and liver tissue were analyzed.

Results

Both YH and exercise significantly reduced the weight of the body and adipose tissues;

SUBMITTER: Kim N 

PROVIDER: S-EPMC11967133 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature