Prevalence and risk factors of gross neurologic deficits in children after severe malaria: a systematic review protocol.

ABSTRACT:

Background

Children exposed to severe malaria may recover with gross neurologic deficits (GND). Several risk factors for GND after cerebral malaria (CM), the deadliest form of severe malaria, have been identified in children. However, there is inconsistency between previously reported and more recent findings. Although CM patients are the most likely group to develop GND, it is not clear if other forms of severe malaria (non-CM) may also contribute to malaria-related GND. The objective of this systematic review is to synthesize evidence on the prevalence and risk factors for GND in children after severe malaria.

Methods

The systematic review will be conducted according to recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Protocols

SUBMITTER: Okullo AE 

PROVIDER: S-EPMC11967140 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature