A prospective study of early pregnancy metal concentrations and gestational diabetes mellitus based on a birth cohort in Northwest China.

ABSTRACT:

Background

Exposure to metals during early pregnancy may affect maternal glucose metabolism. We were aimed to assess the associations between early pregnancy whole blood concentrations of copper (Cu), zinc (Zn), calcium (Ca), iron (Fe), and magnesium (Mg) with GDM later in the second trimester among pregnant women in Northwest China.

Methods

This study included 5478 first-trimester pregnant women who participated in the birth cohort of the Northwest Women's and Children's Hospital between July 2018 and December 2023. Metal concentrations, basic demographic characteristics, lifestyle and behavior patterns were collected. An oral glucose tolerance test was performed in the second trimester. A generalized linear model was used to analyze the effects of metal concentrations on G

SUBMITTER: Zhao D 

PROVIDER: S-EPMC11967153 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature