Supersulfide metabolome of exhaled breath condensate applied as diagnostic biomarkers for esophageal cancer.

ABSTRACT: Early detection of esophageal cancer is essential for esophagogastroduodenoscopy and histopathological diagnosis. However, endoscopic examinations are sometimes invasive, which limits their clinical application and compliance, and traditional blood tumor markers are unsuitable for cancer screening. The current study aimed to evaluate the usefulness of sulfur metabolites as new biomarkers for esophageal cancer using blood samples and exhaled breath condensate (EBC), which can be readily obtained and is non-invasive. We collected EBC and plasma samples from 50 patients with esophageal cancer and 30 healthy controls. Sulfur metabolome analysis using tandem mass spectrometry was performed to compare the metabolic profile between the two groups. Supersulfide metabolic profiles were different be

SUBMITTER: Asamitsu S 

PROVIDER: S-EPMC11967250 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature