Susceptibility of Brca1^(L63X/+) rat to ovarian reserve dissipation by chemotherapeutic agents to breast cancer.

ABSTRACT: BRCA1 is one of the causative genes for hereditary breast and ovarian cancer syndrome with a high risk of early-onset breast cancer. Whereas olaparib (OLA), an inhibitor of poly-ADP-ribose polymerase, has been applied as adjuvant therapy to those cancer patients, its effect on ovarian reproductive function remains unelucidated. Recently, a rat model (MUT; Brca1^(L63X/+) mutation) mimicking a human BRCA1 pathogenic variant has been established. Using this model, we evaluated the effects of OLA on ovarian reproductive function in comparison with the wild-type (WT) rats. MUT showed a significantly reduced number of primordial follicles and subfertility in accordance with aging. Oxidative stress was significantly elevated in the young MUT granulosa cells (GCs) accompanied by increase

SUBMITTER: Kaseki S 

PROVIDER: S-EPMC11967261 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature