T_H17/Treg lymphocyte balance is regulated by beta adrenergic and cAMP signaling.

ABSTRACT:

Background

Post-traumatic stress disorder (PTSD) is a debilitating psychological disorder that also presents with neuroimmune irregularities. Patients display elevated sympathetic tone and are at an increased risk of developing secondary autoimmune diseases. Previously, using a mouse model of repeated social defeat stress (RSDS) that recapitulates certain features of PTSD, we demonstrated that elimination of sympathetic signaling to T-lymphocytes specifically limited their ability to produce pro-inflammatory interleukin 17A (IL-17A); a cytokine implicated in the development of many autoimmune disorders. However, the mechanism linking sympathetic signaling to T-lymphocyte IL-17A production remained unclear.

Methods

Using a modified version of RSDS that allows for both males a

SUBMITTER: Lauten TH 

PROVIDER: S-EPMC11967417 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature