Rituximab versus placebo for chronic inflammatory demyelinating polyradiculoneuropathy: a randomized trial.

ABSTRACT: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) often requires prolonged ongoing treatment to prevent worsening. The efficacy of rituximab in preventing worsening after the discontinuation of immunoglobulin therapy in patients with CIDP was assessed. In this randomized, double-blind, placebo-controlled study, conducted at seven Italian hospitals, CIDP patients under immunoglobulin therapy were assigned to receive either rituximab (1 g on Days 1, 15 and 180 ± 7) or placebo. Both groups continued their regular immunoglobulin doses for 6 months post-intervention. The primary end point was the proportion of patients who worsened in any of the following three measures at Month 12, within 6 months after immunoglobulin discontinuation: a decrease of at least one point on the adju

SUBMITTER: Nobile-Orazio E 

PROVIDER: S-EPMC11967823 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature