A Gallbladder-Specific Hydrophobic Bile Acid-FXR-MUC1 Signaling Axis Mediates Cholesterol Gallstone Formation.

ABSTRACT: Differences in the distribution of hydrophilic and hydrophobic bile acids (BA) are observed in mouse models of non-alcoholic fatty liver disease (NAFLD) induced by a high-fat-cholesterol "Western-style" diet (WD), and cholesterol gallstone disease (CGD) induced by a lithogenic diet. Despite sharing common pathological processes, these models exhibit distinct characteristics in their BA pools. The study investigates the impact of hydrophobic BA (^HphoBA) and hydrophilic BA (^HphilBA) on CGD development using cytochrome-P450-2c70 knockout (C70-KO) mice (mice^C70-KO), genetically modified to resemble humans with a hydrophobic BA pool. All mice^C70-KO fed the WD develop CGD, resembling human cholelithiasis patients, while WD-fed wild-type (WT) mice (mice

SUBMITTER: Chen H 

PROVIDER: S-EPMC11967835 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature