Mendelian randomization study showed no causality between metformin treatment and polycystic ovary syndrome.

ABSTRACT:

Background

Despite previous clinical studies providing some evidence of an association between metformin treatment and polycystic ovary syndrome(PCOS), these findings remain controversial. To investigate whether the association reflect causality, a two-sample Mendelian randomization (MR) method was conducted.

Methods

Data from genome-wide association studies were analyzed, with the exposure factor being metformin and the outcome variable being PCOS. The inverse variance weighted(IVW) was used as the primary method for MR analysis. In addition, MR-Egger, weighted median, heterogeneity tests, and sensitivity analyses were performed.

Results

The initial and validation MR analyses indicated that genetically predicted metformin treatment had no effects on PCOS. Sensitivity

SUBMITTER: Lin L 

PROVIDER: S-EPMC11967963 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature