A longitudinal investigation of the relationship between dimensional psychopathology, gray matter structure, and dementia status in older adulthood.

ABSTRACT:

Background

The structure of psychopathology can be organized hierarchically into a set of transdiagnostic dimensional phenotypes. No studies have examined whether these phenotypes are associated with brain structure or dementia in older adults.

Methods

Data were drawn from a longitudinal study of older adults aged 70-90 years at baseline (N = 1072; 44.8% male). Confirmatory factor models were fit to baseline psychiatric symptoms, with model fit assessed via traditional fit indices, model-based reliability estimates, and evaluation of model parameters. Bayesian plausible values were generated from the best-fitting model for use in subsequent analyses. Linear mixed models examined intraindividual change in global and regional gray matter volume (GMV) and cortical thickn

SUBMITTER: Hoy N 

PROVIDER: S-EPMC11968117 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature