A generalized reward processing deficit pathway to negative symptoms across diagnostic boundaries.

ABSTRACT:

Background

Negative symptoms are a key feature of several psychiatric disorders. Difficulty identifying common neurobiological mechanisms that cut across diagnostic boundaries might result from equifinality (i.e., multiple mechanistic pathways to the same clinical profile), both within and across disorders. This study used a data-driven approach to identify unique subgroups of participants with distinct reward processing profiles to determine which profiles predicted negative symptoms.

Methods

Participants were a transdiagnostic sample of youth from a multisite study of psychosis risk, including 110 individuals at clinical high-risk for psychosis (CHR; meeting psychosis-risk syndrome criteria), 88 help-seeking participants who failed to meet CHR criteria and/or who presented

SUBMITTER: Spilka MJ 

PROVIDER: S-EPMC11968125 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature