Effect of administration routes on the efficacy of human umbilical cord mesenchymal stem cells in type 2 diabetic rats.

ABSTRACT:

Background

Human umbilical cord mesenchymal stem cells (UCMSCs) are being investigated in various clinical trials for different conditions, including type 2 diabetes mellitus (T2DM). However, there is limited research on the optimal injection routes for UCMSCs in T2DM, particularly intravenous injection.

Objective

The objective of this study aims to investigate the efficacy of four different administration routes of UCMSCs in treating T2DM rats, including pancreas injection (DP), tail vein injection (DT), intraperitoneal injection (DI), and dorsal pancreatic artery injection (DPA).

Results

After two weeks of UCMSCs treatment, the fasting blood glucose levels in the DT group decreased significantly. The oral glucose tolerance test (OGTT) levels and the islet structure

SUBMITTER: Tao Q 

PROVIDER: S-EPMC11968364 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature