Stimulating human prefrontal cortex increases reward learning.

ABSTRACT: Work in computational psychiatry suggests that mood disorders may stem from aberrant reinforcement learning processes. Specifically, it has been proposed that depressed individuals believe that negative events are more informative than positive events, resulting in higher learning rates from negative outcomes (Pulcu and Browning, 2019). In this proof-of-concept study, we investigated whether transcranial direct current stimulation (tDCS) applied to dorsolateral prefrontal cortex, as commonly used in depression treatment trials, might change learning rates for affective outcomes. Healthy adults completed an established reinforcement learning task (Pulcu and Browning, 2017) in which the information content of reward and loss outcomes was manipulated by varying the volatility of stimulus-outc

SUBMITTER: Overman MJ 

PROVIDER: S-EPMC11968408 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature