Burden of orofacial clefts from 1990-2021 at global, regional, and national levels.

ABSTRACT:

Objectives

We aimed to study and comprehensively evaluate the burden of OFCs at global, regional, and national levels.

Methods

Based on data from the Global Burden of Disease database for 2021, we analysed the prevalence, mortality, and disability-adjusted life years (DALYs) of orofacial clefts (OFCs) from 1990-2021, categorised by sex, regions, and sociodemographic index (SDI). Numbers and age-standardised rates (ASRs) of the aforementioned indices were estimated through a systematic analysis of modelled data from the GBD 2021 study. Finally, the relationship between SDI and the epidemiological parameters of OFCs was evaluated.

Results

In 2021, the global prevalence of OFCs included 4,124,007 cases, resulting in 1,719 deaths and 408,775 DALYs. From 1990-2021, prevale

SUBMITTER: Ma Q 

PROVIDER: S-EPMC11968431 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature