Mapping Lesion-Related Human Aggression to a Common Brain Network.

ABSTRACT:

Background

Aggression exacts a significant toll on human societies and is highly prevalent among neuropsychiatric patients. The neural mechanisms of aggression are unclear and treatment options are limited.

Methods

Using a recently validated lesion network mapping technique, we derived an aggression-associated network by analyzing data from 182 patients who had experienced penetrating head injuries during their service in the Vietnam War. To test whether damage to this lesion-derived network would increase the risk of aggression-related neuropsychiatric symptoms, we used the Harvard Lesion Repository (N = 852). To explore potential therapeutic relevance of this network, we used an independent deep brain stimulation dataset of 25 patients with epilepsy, in which irritability

SUBMITTER: Peng S 

PROVIDER: S-EPMC11968440 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature