Unanticipated differences in the rat plasma metabolome of genistein and daidzein.

ABSTRACT: Genistein (GEN) and daidzein (DAI) are soy isoflavones known to bind to estrogen receptors. Overall health effects of GEN and DAI in humans exhibit a dual nature, presenting both health benefits and concerns related to their interaction with the estrogen receptor. The metabolomes of these isoflavones were determined in 28-day oral studies in male and female Wistar rats to elucidate (1) metabolites changes, (2) compare their metabolomes with other compounds and (3) identify toxicological modes of action (MoA). Dose levels for GEN were 1000 and 300 mg/kg bw by gavage and 1000 and 300 ppm (via diet). DAI gavage dose levels were 1000 and 100 mg/kg bw. Results were evaluated using the MetaMap^®Tox data base. Both compounds demonstrated metabolome profiles which were associated with es

SUBMITTER: Montoya G 

PROVIDER: S-EPMC11968494 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature