A benchmark concentration-based strategy for evaluating the combined effects of genotoxic compounds in TK6 cells.

ABSTRACT: Chemical risk assessment has historically focused on single compounds, neglecting the implications of combined exposures. To bridge this gap, several methodologies, such as concentration addition (CA) and independent action (IA), have been developed. However, a systematic, consistent, and integrated approach across various legislative frameworks is still lacking. The assessment of combined effects of genotoxicants is even more challenging, as genotoxicity data are typically evaluated qualitatively, without considering the effect size. This study aimed to develop a quantitative approach for evaluating the combined effects of genotoxic compounds with both similar and dissimilar modes of action (MoA), based on the benchmark concentration (BMC) principle. A proof-of-concept study was conducted

SUBMITTER: Sanders J 

PROVIDER: S-EPMC11968543 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature