Identification of ferroptosis-related gene signatures as a novel prognostic model for clear cell renal cell carcinoma.

ABSTRACT:

Background

Clear cell renal cell carcinoma (ccRCC), a common type of renal cortical tumor, is the most prevalent subtype of renal malignancies within the urinary system and is associated with a low survival rate. Ferroptosis plays a crucial role in the process of renal carcinogenesis and holds potential for significant applications in patient prognosis. However, the clinical prognostic relevance of ferroptosis-related genes (FRGs) for ccRCC remains unclear. The identification of FRG signatures and the development of a novel prognostic model based on FRGs demonstrate important prognostic significance for ccRCC.

Methods

Univariate cox screen was performed to screen for prognostic-related genes using ccRCC data from the The Cancer Genome Atlas (TCGA) database. And then an initi

SUBMITTER: Du X 

PROVIDER: S-EPMC11968612 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature