De-escalation of regional nodal irradiation fields in pT1-2N1 breast cancer patients after breast conserving surgery: retrospective real-world clinical experience.

ABSTRACT:

Purpose

Regional nodal irradiation (RNI) in pN1 patients with one to three positive axillary lymph node breast cancers remains controversial. This study aimed to evaluate the impact of RNI in patients with pT1-2N1 breast cancer who underwent radiotherapy after breast-conserving surgery (BCS), focusing on risk stratification and defining the extent of RNI as axillary lymph node levels I and II.

Methods

Female patients with pT1-2N1 breast cancer after BCS with axillary lymph node dissection or sentinel lymph node biopsy who were treated with radiotherapy between 2009 and 2021 were identified. Radiotherapy included either whole-breast irradiation (WBI) alone or WBI with RNI to axillary levels I and II. Patients were categorized into three risk groups based on pathological T sta

SUBMITTER: Hong JH 

PROVIDER: S-EPMC11968704 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature