<i>Pseudomonas aeruginosa</i> enhances anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8⁺ T cells.

ABSTRACT:

Background

Immune checkpoint therapy for colorectal cancer (CRC) has been found to be unsatisfactory for clinical treatment. Fecal microbiota transplantation (FMT) has been shown to remodel the intestinal flora, which may improve the therapeutic effect of αPD-1. Further exploration of key genera that can sensitize cells to αPD-1 for CRC treatment and preliminary exploration of immunological mechanisms may provide effective guidance for the clinical treatment of CRC.

Methods

In this study, 16S rRNA gene sequencing was analyzed in the fecal flora of both responders and no-responders to αPD-1 treatment, and the therapeutic effect was experimentally verified.

Results

Pseudomonas aeruginosa was found to be highly abundant in the fecal flora of treated mice, and P

SUBMITTER: Chen L 

PROVIDER: S-EPMC11968734 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature